Sepsis is today considered a world health problem which yearly affects 50 million people globally, whereof 11 million die.
Sepsis is a severe acute host reaction to pathogen-driven infections that cause systemic inflammation, thrombosis, bleeding, and multiple organ dysfunction syndromes, leading to substantial disability and death. Sepsis affects 50 million people per year globally, whereof 11 million die1 . Many survivors require organ transplantation or suffer life-long disabilities such as limb amputation, dialysis, and cognitive impairments
There is no approved treatment for sepsis or septic shock on the market. Available nonspecific drugs address either coagulation or inflammation, the two crucial pathways involved in sepsis and septic shock pathogenesis. However, by only targeting one of these crucial pathways, existing drugs fail to prevent poor clinical outcomes. Thus, there is an urgent unmet need for novel drugs that effectively inhibit both coagulation disorders and out of control inflammation (cytokine storm) to improve clinical outcomes.
- WHO calls for global action on sepsis – cause of 1 in 5 deaths worldwide. Available from: https://www.who.int/news/item/08-09-2020-who-calls-for-global-action-on-sepsis—cause-of-1-in-5-deaths-worldwide